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CASE REPORT
Year : 2012  |  Volume : 39  |  Issue : 3  |  Page : 147-148

Chondrolipoma of breast: A case report with the review of the literature


Department of Pathology, Pd. Dr. D. Y. Patil Medical College, Nerul, Navi Mumbai, Maharashtra, India

Date of Web Publication11-Jan-2013

Correspondence Address:
S Sudhamani
Department of Pathology, Pd. Dr. D. Y. Patil Medical College, Nerul, Navi Mumbai, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-5009.105923

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  Abstract 

Chondrolipoma of the breast is a rare benign mesenchymal tumor composed of mature cartilage and adipose tissue. We present one such case in a 55-year-old woman presenting with left breast lump detected by self-examination. The tumor was diagnosed as fibroadenoma clinically. The diagnosis of chondrolipoma was possible only by histopathological examination. This case is reported because of its rarity in breast.

Keywords: Benign breast tumor, chondrolipoma, mesenchymal tumor breast


How to cite this article:
Sudhamani S, Pandit AA, Kiri V M. Chondrolipoma of breast: A case report with the review of the literature. J Sci Soc 2012;39:147-8

How to cite this URL:
Sudhamani S, Pandit AA, Kiri V M. Chondrolipoma of breast: A case report with the review of the literature. J Sci Soc [serial online] 2012 [cited 2019 Sep 15];39:147-8. Available from: http://www.jscisociety.com/text.asp?2012/39/3/147/105923


  Introduction Top


Benign cartilage containing mesenchymal tumors of the breast are extremely rare. [1] Only 14 cases of chondrolipomas of the breast have been reported so far in the literature. [2] They are composed of fat and nodules of fibro and hyaline cartilage. [3] Clinically it resembles fibroadenoma but may show calcification on mammography mimicking carcinoma. Thus, the diagnosis rests solely on histopathology. Here we report this unusual entity with a review of the literature.


  Case Report Top


A 55-year-old perimenopausal woman came with complaint of lump in the left breast. She noticed it 6 months back as a small lump, which gradually increased to the present size. There was no history of nipple retraction or nipple discharge.

On physical examination, the lump measured 3 × 2 cm in the outer inner quadrant of the left breast, freely mobile, and non-tender. It was not attached to the overlying skin or deeper structures. Skin, nipple, areola, and ipsilateral axilla were unremarkable. Based on these findings, clinical diagnosis of fibroadenoma was made.

Fine needle aspiration cytology (FNAC) and mammography were not done. Routine investigations were within normal limits. The lump was excised and sent for histopathological examination.

We received four yellowish fibrofatty masses, the largest measuring 1.5 × 1 × 1 cms. It was firm, well circumscribed, and partially encapsulated. The cut section showed yellow soft areas and white translucent gritty areas. Other masses also showed similar gross findings. The sections were processed after decalcification.

The microscopic examination revealed a tumor composed of mature adipose tissue intermingled with lobules of hyaline cartilage [Figure 1] and [Figure 2]. A fibrocartilage was seen only occasionally. Few lobules revealed central area of calcification. The mammary tissue was not seen in the tumor. Based on these findings the diagnosis of chondrolipoma was made.
Figure 1: Mature hyaline cartilage surrounded by fat H and E, × 40

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Figure 2: Cartilage showing chondrocytes and surrounding adipocytes. H and E, × 100

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  Discussion Top


Lipomas are occasionally altered by the admixture of other mesenchymal elements that comprise an intrinsic part of the tumor. They are fibrolipoma, myxolipoma, angiolipoma, chondrolipoma, and osteolipoma. Chondrolipoma is considered as cartilaginous metaplasia encountered in lipomas of large size and long duration. [4] Chondrolipoma can be present on the chest wall, back, extremity, breast, tongue, buccal mucosa, etc. [5] Cartilage can be seen in few other benign breast tumors like intraductal papilloma, fibroadenoma, phylloid's tumor, and mammary hamartoma. [5] Cartilaginous tissue is associated mainly with malignancies such as sarcoma and metaplastic carcinoma. [6] Chondrolipomas are generally seen above the age of 50 years, [6] correlating with that of our case. However, calcification is an unusual finding in our case and was seen only in two cases reported previously. [6],[7] The presence of mammary ducts and lobules was reported in one case. [8] However, it was lacking in our case.

In conclusion, it can be said that chondrolipoma of the breast is a rare benign tumor and can be confused with malignant tumor on mammography. Therefore, excision is necessary as well as useful in providing an exact diagnosis.

 
  References Top

1.Schnitt SJ, Mills RR, Hanby AM, Oberman HA. The breast. In: Mills SE, editor. Sternberg's diagnostic surgical pathology. 4 th ed. Philadelphia: Lippincott Williams and Wilkins; 2004. p. 385.  Back to cited text no. 1
    
2.Banev SG, Filipovski VA. Chondrolipoma of the breast: A case report and review of literature. Breast 2006;15:425-6.  Back to cited text no. 2
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3.Coulson WF, Rosen VJ. The breast. In: Coulson WF, editor. Surgical pathology. 2 nd ed. Philadelphia: J.B. Lippincott Company; 1988. p. 837.  Back to cited text no. 3
    
4.Weiss SW, Goldblum JR. Cartilaginous soft tissue tumors. In: Strauss M, editor. Enzinger and Weiss's Soft tissue tumors. 4 th ed. St. Louis: Mosby; 2001. p. 1361.  Back to cited text no. 4
    
5.Ohtsuka H. Chondrolipoma of the popliteal fossa and Japanese reports. J Dermatol 2006;33:202-6.  Back to cited text no. 5
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6.Perez MT, Alexis JB. Chondrolipoma of the breast presenting as calcifications in a routine mammogram. Histopathology 1999;35:189-90.  Back to cited text no. 6
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7.Kaplan L, Walts AE. Benign chondrolipomatous tumor of the human female breast. Arch Pathol Lab Med 1977;101:149-51.  Back to cited text no. 7
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8.Baric A, Jewell W, Chang CH, Damjanov I. Chondrolipoma of the breast. Breast J 2005;11:212-3.  Back to cited text no. 8
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  [Figure 1], [Figure 2]



 

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