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Year : 2014  |  Volume : 41  |  Issue : 3  |  Page : 232-235

Depression and cancer: An update

1 Department of Psychiatry, Subharti Medical College, Meerut, Uttar Pradesh, India
2 Department of Pathology, Lala Lajpat Rai Memorial Medical College, Meerut, Uttar Pradesh, India
3 Department of Psychiatry, Lady Hardinge Medical College, New Delhi, India
4 Department of Psychiatry, King George's Medical College, Lucknow, Uttar Pradesh, India

Correspondence Address:
Monika Rathi
228/16, Saket Colony, North Civil Lines, Muzaffarnagar, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-5009.141258

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A large number of psychosocial factors are associated with cancer. Depression is one of these important associated factors. It is hypothesized that depression compromises the immune system and results in dysregulation of deoxyribonucleic acid repair enzymes, leading to subsequent development of cancers. The association between depression and cancer has always been debatable and controversial. We decided to conduct a new systematic review to investigate, if the conclusion, about depression being a risk factor for cancer development still holds true. We did extensive literature search at databases like PubMed, MedLine and EBSCO. Our review suggests the significantly increased association between depression and cancer, especially breast cancer.

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