Journal of the Scientific Society

REVIEW ARTICLE
Year
: 2014  |  Volume : 41  |  Issue : 3  |  Page : 227--231

Lacosamide: A novel antiepileptic and anti-nociceptive drug on the block


Sukhminder Jit Singh Bajwa1, Ashish Kulshrestha2 
1 Department of Anaesthesiology and Intensive Care, Gian Sagar Medical College & Hospital, Banur, Punjab, India
2 Department of Anaesthesiology and Intensive Care, Government medical college and hospital, Chandigarh, India

Correspondence Address:
Sukhminder Jit Singh Bajwa
House No. 27-A, Ratan Nagar, Tripuri, Patiala, Punjab
India

With an increasing demand for newer anti-epileptic agents having a better pharmacological profile, many newer agents are being investigated. Lacosamide is a newer functional amino acid being developed as an adjunctive therapy for resistant partial-onset seizures owing to its activity of enhancing the slow inactivation of voltage-gated sodium channels thereby reducing pathologic hyperactivity in neurons. It has also being investigated for its role as anti-nociceptive in variety of pain scenarios specifically in diabetic neuropathic pain. It is well-absorbed orally, metabolized in liver and excreted by the kidneys. It has a favorable pharmacologic profile in having minimal drug interactions. The adverse effects include mild dizziness, behavioral changes and dose dependent prolongation of PR interval. This review is directed toward the development of lacosamide and its potential usefulness as an anti-epileptic and an anti-nociceptive drug.


How to cite this article:
Bajwa SS, Kulshrestha A. Lacosamide: A novel antiepileptic and anti-nociceptive drug on the block.J Sci Soc 2014;41:227-231


How to cite this URL:
Bajwa SS, Kulshrestha A. Lacosamide: A novel antiepileptic and anti-nociceptive drug on the block. J Sci Soc [serial online] 2014 [cited 2020 May 26 ];41:227-231
Available from: http://www.jscisociety.com/article.asp?issn=0974-5009;year=2014;volume=41;issue=3;spage=227;epage=231;aulast=Bajwa;type=0