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Year : 2019  |  Volume : 46  |  Issue : 2  |  Page : 46-48

The association between glycemic control and non-high density lipoprotein cholesterol in type 2 diabetic patients

1 Department of Biochemistry, KAHER (Deemed-to-be-University), Jawaharlal Nehru Medical College, Belagavi, Karnataka, India
2 Department of General Medicine, KAHER (Deemed-to-be-University), Jawaharlal Nehru Medical College, Belagavi, Karnataka, India

Correspondence Address:
Dr. Chetana Prabhu Hadimani
Department of Biochemistry, KAHER (Deemed-to-be-University), Jawaharlal Nehru Medical College, Belagavi, Karnataka
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jss.JSS_12_19

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Introduction: Diabetes mellitus (DM) is a group of common metabolic disorders that is characterized by hyperglycemia. It is reported that most patients with Type 2 diabetes could have dyslipidemia at varying degrees, characterized by the increased levels of triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). The non-HDL-C was introduced to refine the risk estimation beyond LDL-C in the presence of elevated TGs levels ≥200 mg/dl, and it also estimates the level of all Apo-B-carrying lipoproteins. This study was conducted to correlate the glycated hemoglobin with non-HDL-C and lipid profile in Type 2 DM and non-DM patients. Materials and Methods: The present case and control study was conducted on 204 participants who attended the Medical Outpatient Department at KLE's Hospital, Belagavi, Karnataka, India. 102 Type 2 diabetic patients and 102 age- and gender-matched healthy controls were evaluated for serum fasting blood sugar (FBS), blood HbA1c, serum fasting lipid profile, and non-HDL-C. Data were analyzed using the SPSS software version. 20. Results: The results of our study showed that the mean ± standard deviation levels of FBS were 157.18 ± 41.8 and HbA1c was 8.19 ± 1.68, which were significantly increased in Type 2 diabetes patients as compared to controls with FBS 99.96 ± 12.94 and HbA1C 5.56 ± 0.40 with P < 0.05. The levels of total cholesterol, LDL-C, and TGs significantly increased in cases as compared to controls with P < 0.05. Whereas, non-HDL-C levels significantly increased in cases 147.75 ± 30.42 as compared to controls 111.26 ± 31.9 with P < 0.05. Conclusion: The result of this study showed that HbA1c was associated with a significant increase in non-HDL levels in cases as compared to controls. Thus, non-HDL-C preferred as one of the markers for diabetic dyslipidemia and cardiovascular risk marker than LDL alone.

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