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ORIGINAL ARTICLE
Year : 2020  |  Volume : 47  |  Issue : 3  |  Page : 144-147

Viral load and genotype of recent hepatitis E virus outbreak in Chittagong, Bangladesh


1 Department of Medicine and Microbiology, Chattogram Maa O Shishu Hospital Medical College, Agrabad, Chittagong, Bangladesh
2 Department of Medicine, Chattogram Maa O Shishu Hospital Medical College, Agrabad, Chittagong, Bangladesh
3 Department of Microbiology, Chattogram Maa O Shishu Hospital Medical College, Agrabad, Chittagong, Bangladesh
4 Department of Laboratory Medicine, SlieaGen LLC, Austin, TX, USA

Correspondence Address:
Dr. Rajat Sanker Roy Biswas
Department of Medicine, Agrabad, Chittagong
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jss.JSS_42_19

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Introduction: There is an outbreak of hepatitis E virus (HEV) infection in Chittagong, Bangladesh in the year 2018. Due to unavailability of data of HEV infections in this region, objectives of the present study are to find the viral load and genotype the HEV infections. Methods: It was an observational study done in a tertiary care hospital during one year. A total of 125 Ig-M HEV positive cases were recruited tested by ELISA. After collection blood samples those were sent to Sliea Gen L.L.C, Texas, USA for detection of viral load and genotype maintaining proper procedure. Ethical clearance was taken from the hospital authority and informed written consent was taken from all patients and funding was provided by Sliea Gen L.L.C. USA. Results: Among the total 125 study patients, male was 90(72') and female was 35(29') where 7(5.6') were pregnant. Among them most 45(36.0') were at age group 30-40 years. Mean ± SD of age was 33.78 ± 14.29 years. All (100') cases were Ig-M Anti HEV positive and 9(7.2') cases were also positive for HBsAg, 1(0.8') cases were Anti HCV positive and none was Anti HAV positive. Regarding viral load Log 4-6 were found in 55(44.0') cases and >Log 6 were found in 23(18.4') cases and again 30(24.0') cases had 1000-10,000 IU/ml, 25(20.0') cases had 1,0,000-1,00,000 IU/ml and 23(18.4') cases had 1.00,000- 10,00,000 IU/ml viral load. Genotype 1F was found in 68(54.4') cases as the only genotype and no other genotype was found in the sample. Conclusion: So, in this region Chittagong, Bangladesh genotype 1F is the main genotype found and also they showed variable viral load.


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