| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 47
| Issue : 3 | Page : 180-184 |
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Significance of human epidermal growth factor receptor 2 neu immunostain in head and neck squamous cell carcinoma
Ponkhi Doley, Srinivasamurthy Venkataramanappa, Panduranga Chikkannaiah
Department of Pathology, Employees' State Insurance Corporation Medical College, PGIMSR, Bengaluru, Karnataka, India
Correspondence Address:
Dr. Panduranga Chikkannaiah
Department of Pathology, Employees' State Insurance Corporation Medical College, PGIMSR, Bengaluru - 560 010, Karnataka
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jss.JSS_60_20
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Introduction: Squamous cell carcinoma is the most common head and neck cancer. In spite of advances in the diagnosis and treatment, a prognosis still remains poor. Head-and Neck squamous cell carcinoma (HNSCC) is found to express human epidermal growth factor receptor 2 (Her 2) neu marker. Materials and Methods: The present study was conducted for a period of 1 year from January to December 2017. All the cases which have been pathologically diagnosed as HNSCC were included in the study. Results: During the study period, a total of 50 cases were observed. Male: female ratio was 1.7:1. In our study, buccal mucosa was the most common site (26'). Well-differentiated morphology was more common (36'), and 34' cases were positive for Her 2 Neu expression. Conclusion: Her 2 neu expression may not be a reliable molecular prognostic marker for HNSCC.
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