Journal of the Scientific Society

: 2012  |  Volume : 39  |  Issue : 3  |  Page : 147--148

Chondrolipoma of breast: A case report with the review of the literature

S Sudhamani, Ajita A Pandit, VM Kiri 
 Department of Pathology, Pd. Dr. D. Y. Patil Medical College, Nerul, Navi Mumbai, Maharashtra, India

Correspondence Address:
S Sudhamani
Department of Pathology, Pd. Dr. D. Y. Patil Medical College, Nerul, Navi Mumbai, Maharashtra


Chondrolipoma of the breast is a rare benign mesenchymal tumor composed of mature cartilage and adipose tissue. We present one such case in a 55-year-old woman presenting with left breast lump detected by self-examination. The tumor was diagnosed as fibroadenoma clinically. The diagnosis of chondrolipoma was possible only by histopathological examination. This case is reported because of its rarity in breast.

How to cite this article:
Sudhamani S, Pandit AA, Kiri V M. Chondrolipoma of breast: A case report with the review of the literature.J Sci Soc 2012;39:147-148

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Sudhamani S, Pandit AA, Kiri V M. Chondrolipoma of breast: A case report with the review of the literature. J Sci Soc [serial online] 2012 [cited 2021 Oct 21 ];39:147-148
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Benign cartilage containing mesenchymal tumors of the breast are extremely rare. [1] Only 14 cases of chondrolipomas of the breast have been reported so far in the literature. [2] They are composed of fat and nodules of fibro and hyaline cartilage. [3] Clinically it resembles fibroadenoma but may show calcification on mammography mimicking carcinoma. Thus, the diagnosis rests solely on histopathology. Here we report this unusual entity with a review of the literature.

 Case Report

A 55-year-old perimenopausal woman came with complaint of lump in the left breast. She noticed it 6 months back as a small lump, which gradually increased to the present size. There was no history of nipple retraction or nipple discharge.

On physical examination, the lump measured 3 × 2 cm in the outer inner quadrant of the left breast, freely mobile, and non-tender. It was not attached to the overlying skin or deeper structures. Skin, nipple, areola, and ipsilateral axilla were unremarkable. Based on these findings, clinical diagnosis of fibroadenoma was made.

Fine needle aspiration cytology (FNAC) and mammography were not done. Routine investigations were within normal limits. The lump was excised and sent for histopathological examination.

We received four yellowish fibrofatty masses, the largest measuring 1.5 × 1 × 1 cms. It was firm, well circumscribed, and partially encapsulated. The cut section showed yellow soft areas and white translucent gritty areas. Other masses also showed similar gross findings. The sections were processed after decalcification.

The microscopic examination revealed a tumor composed of mature adipose tissue intermingled with lobules of hyaline cartilage [Figure 1] and [Figure 2]. A fibrocartilage was seen only occasionally. Few lobules revealed central area of calcification. The mammary tissue was not seen in the tumor. Based on these findings the diagnosis of chondrolipoma was made.{Figure 1}{Figure 2}


Lipomas are occasionally altered by the admixture of other mesenchymal elements that comprise an intrinsic part of the tumor. They are fibrolipoma, myxolipoma, angiolipoma, chondrolipoma, and osteolipoma. Chondrolipoma is considered as cartilaginous metaplasia encountered in lipomas of large size and long duration. [4] Chondrolipoma can be present on the chest wall, back, extremity, breast, tongue, buccal mucosa, etc. [5] Cartilage can be seen in few other benign breast tumors like intraductal papilloma, fibroadenoma, phylloid's tumor, and mammary hamartoma. [5] Cartilaginous tissue is associated mainly with malignancies such as sarcoma and metaplastic carcinoma. [6] Chondrolipomas are generally seen above the age of 50 years, [6] correlating with that of our case. However, calcification is an unusual finding in our case and was seen only in two cases reported previously. [6],[7] The presence of mammary ducts and lobules was reported in one case. [8] However, it was lacking in our case.

In conclusion, it can be said that chondrolipoma of the breast is a rare benign tumor and can be confused with malignant tumor on mammography. Therefore, excision is necessary as well as useful in providing an exact diagnosis.


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